To troubleshoot this specific error, try:

I stared at the numbers. They weren't just code; they were a judgment. An execution notice for my playthrough. I mashed the 'Esc' key. I mashed 'Alt+F4'. The window remained, stubborn, mocking me. I had to Ctrl+Alt+Delete and end the task forcefully, watching my dreams of criminal empire domination vanish into the void of the Windows Task Manager.

(by Silent, a famous modder).

Running the game as if it were on an older operating system can bypass modern architecture conflicts. Right-click gta-vc.exe and select . Go to the Compatibility tab.

The most frequent cause is DEP blocking the game from executing code in protected memory regions.

Sometimes the crash occurs because the game is trying to load a resolution or audio setting that your current hardware no longer supports. Navigate to your folder. Open the GTA Vice City User Files folder. Locate the file named gta_vc.set and delete it.