Do not use aggressive cleaners. Instead, if you have multiple conflicting entries, delete the entire KonamiPES key in both HKLM\SOFTWARE\WOW6432Node and HKCU\Software , then re-import the correct .reg file from Method 1.
The only reason I didn't give it a perfect score is that I had to run the game in compatibility mode (Windows XP SP2) to avoid some minor graphical glitches. However, this is a minor quibble, and the fix itself is not at fault.
Paste the code below, ensuring you replace C:\\Your\\Path\\To\\PES6 with your actual installation folder (use double backslashes \\ ).
@echo off set "regpath=HKEY_LOCAL_MACHINE\SOFTWARE\WOW6432Node\KONAMIPES6\PES6" set "installpath=%~dp0" reg add "%regpath%" /v "installdir" /t REG_SZ /d "%installpath%" /f echo Registry updated to %installpath% pause