A: No. A real PS2 cannot read CHD or CSO files. You must use an emulator (PCSX2, AetherSX2). For a real PS2, you need an untouched ISO and a modchip.

: It maintains all original data but shrinks the "zero-fill" space common in PS2 discs.

Modding PS2 for ISO Game Playback | PDF | System Software - Scribd

: A standard PS2 ISO can be large, but "highly compressed" versions (often in .7z or .rar format) bring it down to roughly 600 MB .